阅读英文文献汇报—流感病毒M2与自噬关系.pptxVIP

Matrix Protein 2 of Influenza A Virus BlocksAutophagosome Fusion with Lysosomes;Influenza A virus inhibits macroautophagy, a cellular process known to be manipulated by diverse pathogens. Influenza A virus infection causes accumulation of autophagosomes by blocking their fusion with lysosomes, and one viral protein matrix protein 2, is necessary and sufficient for this inhibition of autophagosome degradation. Macroautophagy inhibition by matrix protein 2 compromises survival of influenza virus-infected cells but does not influence viral replication. We propose that influenza A virus, which al