CML的实验室检测解说.pptxVIP

CML的实验室检测概述;CML的病因和治疗;CML的主要实验室检测项目;RQ-PCR定量检测BCR-ABL1 mRNA;为什么RQ-PCR检测灵敏度更高？;RQ-PCR的影响因素;RQ-PCR的影响因素;RQ-PCR定量值的国际标准化（IS）;标本送检：骨髓还是外周血？;BCR-ABL1定量报告;BCR-ABL1定量值:降的越快越安全;TKIs耐药突变;TKIs耐药突变和检测方法学;耐药突变产生的内在原因;Imatinib增加CML肿瘤干细胞中氧自由基和DNA氧化损伤 ;Drug Resistance and BCR-ABL Kinase Domain Mutations in Philadelphia hromosome–Positive Acute Lymphoblastic Leukemia; From the Imatinib to the Second-Generation Tyrosine Kinase Inhibitor Era Simona Soverini, et al. Cancer 2014;120:1002–9.;换用二代TKIs后基因突变的动态变化;耐药突变动态变化的根源在于耐药性的差别;TKIs耐药突变的出现和消长;各种突变的耐药数据不好记怎么办？关注微信服务号“道培检验”，随时查询！关键词“TKIR”“TKIS”;TKIs血药浓度检测;Deep Molecular Response Is Reached by the Majority of Patients Treated With Imatinib, Predicts Survival, and Is Achieved More Quickly by Optimized High-Dose Imatinib: Results From the Randomized CML-Study IV Rudiger Hehlmann, et al. J Clin Oncol 2014,32:415-423.;本实验室ALL患者Imatinib（格列卫）血浆浓度检测结果;Imatinib血药浓度检测;遗传多态性影响TKIs疗效？;Annette S. Gillings, et al. FEBS Journal 276 (2009) 6050–62;BCL2L11（BIM）基因遗传缺失型/SNP与TKI治疗反应有关？;我们的资料;谢谢关注！