药代动力学研究分析.docVIP

药物代谢动力学的研究 摘要：超高效液相色谱(UPLC)和PBPK模型在药物代谢动力学研究发挥的重要的作用。UPLC是一种柱效高、发展前景好的液相色谱技术,是一种基于机制的数学模型；PBPK用于模拟化学物质在体内的分布代谢更方面对药物动力学的研究。药物代谢动力学的更深研究在药物研发中起到了重要意义及作用。 关键词：药物代谢动力学 UPLC PBPK模型 药物研发 Abstract: the high performance liquid chromatography (UPLC) and PBPK model in the study of the pharmacokinetic play an important role. UPLC is a column efficiency high, the prospects of the development of good performance liquid chromatography, is based on a mathematical model of the mechanism; PBPK used for simulation of the chemical substances in the body of metabolic distributed more medicine dynamics research