生物钟基因peiod3的多态性及其与睡眠关系的研究进展.docxVIP

 PAGE 7 生物钟基因period3的多态性及其与睡眠关系的研究进展 摘要：昼夜节律是大部分原核生物和所有真核生物具有的生物节律。period3基因是生物钟的核心组成，与睡眠生理密切相关。本文对period3基因的功能研究进展进行综述。 关键词：period3基因，遗传多态性，串联重复多态性，昼夜节律，生物钟 Advances in the Biological Clock Gene Period3 Polymorphism and Relationship with Sleep Abstract： Circadian rhythm is one of the most obvious character of most prokaryotes and eukaryotes. Period3 ( per3 ) is a core component of the circadian clock genes, which are closely associated with sleep physiology. In this paper, the progress of per3 gene function is reviewed. Key Word：period3 gene, genetic polymorphism, variable number tandem repeat (VNTR), circadian rhythm, bio-clock 睡眠为维持正常生理活动所必需。人类的睡眠活动受到一系列因素综合调节，包括外界因素和机体自身调节机制。外界因素包括光照、温度等；机体自身的调节则包括两个相对独立又互相联系的调节机制，昼夜节律和睡眠平衡。 昼夜节律又称生物钟，是周期约为24小时的生理过程；即使在缺乏外界因素的条件下，如光照和温度等，昼夜节律仍能维持原有的生理周期 ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l _ENREF_1 \o Panda, 2002 #1 1]。从光合原核生物到高等真核生物，昼夜节律广泛存在。昼夜节律的标志是机体核心温度和血浆中皮质醇和褪黑素的水平。哺乳动物生物钟的调节中枢位于下丘脑的视交叉上核( suprachiasmatic nuclei, SCN），通过一系列的级联反应，使大脑与全身各个部位的节律趋于一致 ADDIN EN.CITE EndNoteCiteAuthorZhang/AuthorYear2009/YearRecNum2/RecNumDisplayTextstyle face=superscript[2]/style/DisplayTextrecordrec-number2/rec-numberforeign-keyskey app=EN db-id=0ff92ze04900pce59tbvers4awe22ef5vxd02/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorZhang, E. E./authorauthorLiu, A. C./authorauthorHirota, T./authorauthorMiraglia, L. J./authorauthorWelch, G./authorauthorPongsawakul, P. Y./authorauthorLiu, X./authorauthorAtwood, A./authorauthorHuss, J. W., 3rd/authorauthorJanes, J./authorauthorSu, A. I./authorauthorHogenesch, J. B./authorauthorKay, S. A./author/authors/contributorsauth-addressGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA./auth-addresstitlestitleA genome-wide RNAi screen for modifiers of the circadian clock in human cells/titlesecondary-titleCell/secondary-title/titlesperiodicalfull-titleCell/full-title/periodicalpages199-210/pagesvolume139/volumenumber1/numb