补肾化痰祛瘀法治疗血管性认知功能障碍随机对照试验的Meta分析与用药规律研究.pdfVIP

kidney,dissipating phlegm and removing blood stasis; Cluster analysis results indicate that the combination of three methods by removing blood stasis,invigorating kidney and dissipating phlegm;and activating blood is the necessary treatment; invigorating kidney and activating blood supplement and promote each other mutually;③Due to lower overall quality and potential publication bias of included study, we need to promote and develop more randomized controlled trials,which should have the rational design, the execution strictly, the multi-central and large sample, long time follow-up and hold Chinese medicine characteristic;④On account of defects in the aspects of clinical trials and Systematic Review, TCM clinical evaluation should take syndrome differentiation as the connection point and establish evidence-based medicine system of the combination of disease and syndrome based on the characteristics of TCM. Keywords The method of invigorating kidney,dissipating phlegm and removing blood stasis; VCI; RCT; Meta-analysis; Regularity of prescription 目 录 引 言 1 VCI 中西医研究现状 3 1 中医药研究 3 1.1 病名认识 3 1.2 病因病机 3 1.3 治则治法 4 1.4 临床辨证论治 5 1.5 益智中药研究 5 2 西医学研究 8 2.1 发病机制 8 2.2 临床表现 9 2.3 治疗方法 9 中医临床试验系统评价 10 1 研究方法 10 1.1 纳入标准 10 1.2 排除标准 11 1.3 文献检索 11 1.4 数据提取 12 1.5 质量评价 12 1.6 统计分析 12 2 研究结果 13 2.1 文献筛选结果 13 2.2 纳入文献质量 14 2.3 干预措施统计 15 2.4 临床疗效评价 15 2.5 安全性评价 29 2.6 敏感性分析 29 2.7 偏倚分析 32 合格文献用药规律研究 34 1 研究方法 34 1.1 规范数据 34 1.2 统计数据 34 2.研究结果 34 2.1 高频药物 34 2.2 聚类分析 34 讨 论 36 1 系统评价与中医临床决策 36 2 有效性和安全性评价 36 3 用药规律分析与临床意义 36 3.1 单味药物使用频次 36 3.2 各类药物聚类分析 37 4 中医临床评价问题及展望 38 4.1 中医临床试验 38 4.2 临床疗效评价 38 5 本研究的不足之处 39 结 语 40 参考文献 41 附 录 50 致 谢 71 发表文章 72 补肾化痰祛瘀法治疗血管性认知功能障碍随机对照试验的Meta分析和用药规律研究