CKD骨矿物质-血管综合征的防治调研报告.ppt

Vitamin D在抑制PTH的同时升高了钙,磷 ADVANCE研究—钙模拟剂对冠状动脉钙化的作用 ADVANCE研究—西那卡塞对各项主要参数的影响 ADVANCE研究：结论 Therapeutic Interventions for Managing Secondary HPT Active vitamin D sterols are widely used for managing secondary HPT in CKD patients. These drugs mimic the effects of endogenous calcitriol, and thereby supplement the low levels found in CKD. Active vitamin D sterols reduce pre-pro-PTH gene transcription and PTH synthesis, resulting in a decrease in serum PTH levels.1 However, active vitamin D sterols also stimulate intestinal calcium and phosphate absorption, which increases serum calcium and phospha