C5-controlofenzymeactivity解释.ppt

3.2 Protein kinases catalyze the transfer of a phosphate group from an ATP molecule to the side chains of Ser, Thr, or Tyr residues in proteins. 3.3 Protein phosphatases catalyze the hydrolysis of phosphoryl groups attached to proteins, thus reversing the effects of kinases. 3.4 The degree of specificity of protein kinases varies. Some catalyze the phosphorylation of many different target proteins (at sites of conserved sequences, e.g., protein kinase A recognizes a conserved sequence made of Arg-Arg-X-Ser-Z or Arg-Arg-X-Thr-Z). Some phosphorylate a single protein or several closely relate