EGCG棕榈酸酯体外抗HCV作用和机理研究.pdf

通过修饰STAT2激活干扰素通路的抗病毒基因表达正向抑制病毒的增殖，同时特异性与 HSPA5结合降低蛋白的活性负向抑制病毒增殖，两条途径共同作用实现抗病毒作用的。由 于细胞生存在微观与精密并存的环境中，EGCG棕榈酸酯实现细胞内抗病毒的作用的途径 并非简单两个蛋白的改变而已，希望本研究为人类克服丙型肝炎病毒提供依据。 试剂盒；转染：慢病毒包装； II AntiViralefrectsofEGCG on CVirusinVitro palmitateHepatitis and mechanism study Master Jie Grade：20l2 Candidate：Zhang Supervisor：SongDe—gui ResearchDir∞ti仰：Animal Major：Ecology Ecology ABSTRACT an memberSon the Human，as enVironmentalwhen imponant ea吡，are changedby people theirsurViVal theintemalenvironmenthomeostasisof changes enVironment．Though des臼．oying leadto C akindof human，pathogensmanydiseases．Hepatitisvirus(HCV)is global distributed RNA tothevariation ofits single-s仃andedViruses，according regionsequence bediVidedintosix aswellashundredsof of genome，HCVcan genotypes speciessubtypes．After infectionin Viruscan nomlal environmentincells humans，the伊owingchange ecological a ofincubation thatchronic in throughlongperiod period，so hepatitis铲aduallydevelop cancerorfulminant cirrhosis，liVer hepatic inliverfunction lost， failure，resulting completely eVentuallytheliVesofthoseinfected． claiming This aimsat thete