免疫球蛋白E信号受体和气喘.docVIP

Immunoglobulin E ReceptorSignaling and Asthma* First Published on July 28, 2011, doi: 10.1074/jbc.R110.205104 September 23, 2011 The Journal of Biological Chemistry, 286, 32891-32897. Lawren C. Wu1 From the Department of Immunology, Genentech, Incorporated,South San Francisco, California 94080 Elevated IgE levels and increased IgE sensitization to allergensare central features of allergic asthma. IgE binds to the high-affinity Fc_ receptor I(Fc_RI) on mast cells, basophils, anddendritic cells and mediates the activation of these cells uponantigen-induced cross-linking of IgE-bound Fc_RI. Fc_RI