铁缺乏儿童血清转铁蛋白受体的变化和其对铁干预的反应.docVIP

PAGE  PAGE 9 铁缺乏儿童血清转铁蛋白受体的变化及其对铁干预的反应 北京大学公共卫生学院营养与食品卫生学系 (北京 100083) 林晓明 刘文静 龙珠 沈晓毅 唐仪 郭燕梅* 王峙* 提要 目的：观察我国儿童在铁状况正常和不同程度缺铁时，体内sTfR的水平、变化和铁干预后sTfR的反应，为探讨鉴定和筛检人体铁缺乏的新指标提供依据。 方法：初筛北京山区6-14岁儿童1006名，检测其铁生化指标，从中筛选铁正常儿童、ID、IDE和IDA儿童共212名，采用双抗体夹心ELASA法测定sTfR含量，并计算sTfR/㏒SF。对铁缺乏儿童给予口服NaFeEDTA胶囊（60mg元素铁/粒），每次1粒，ID与IDE儿童，每周一次，IDA儿童每周三次，连续9周。补铁后重复测定铁生化指标与sTfR，比较补铁前后sTfR的变化。 结果：ID、IDE、IDA儿童sTfR含量和sTfR/㏒SF值分别为20.03±2.33mg/L，24.57±1.11mg/L，33.69±6.46mg/L和19.36±12.73，22.68±10.11，30.66±8.61，均显著高于正常对照组的18.74±3.06mg/L与9.89±1.74。sTfR与SF、FEP、FSP/Hb和Hb的单因素相关分析及多元回归分析与检验，均显示sTfR与FEP和Hb显著相关，表明sTfR为鉴定IDE与IDA的有意义的指标。它在正常儿童的数值范围是12.5—23.5mg/L。缺铁儿童补充NaFeEDTA后，ID期儿童sTfR含量为16.37±3.10mg/L,明显低于补铁前水平,但在IDE与IDA期没有变化。补铁后sTfR/㏒SF值为11.42±3.12，16.54±4.70，23.59±9.93，与补铁前相比显著降低。 结论：sTfR为鉴定铁缺乏IDE与IDA期的特异指标，sTfR/㏒SF为观察补铁效果的敏感指标，本人群铁正常儿童sTfR数值范围为12.5—23.5mg/L。 关键词：铁缺乏 儿童 sTfR 铁干预 ____________________________________ * 北京市房山区预防医学中心 The change and response on iron supplementation of serum transferrin receptor in children with iron deficiency Lin Xiaoming Liu Wenjing Long Zhu et al (Department of Nutrition and Food Hygiene, School of Public health, Peking University, 100083 Beijing) Abstract Objective: In order to understand the change and response on iron supplementation of serum transferrin receptor(sTfR) in children with iron deficiency. Methods: Blood samples were collected by venopunction, and Iron hematological index was determined in 1006 children aged 6-14 years. STfR were determined in 212 children with Iron normal and ID, IDE, IDA children, and they were supplement with 60mg iron status element (NaFeEDTA) once a week (ID and IDE), and 3 times a week (IDA) for 9 weeks. After iron supplementation iron hematological index and sTfR were determined again, and compared the change of sTfR. Results: The mean levels of sTfR and sTfR/㏒SF in children with ID(n=65), IDE(n=67) , IDA(n=32) wer