1神经胶质瘤的研究意义分析.docx

1 神经胶质瘤的研究意义 神经胶质瘤（Glioma）是最常见的颅内肿瘤，约占所有颅内肿瘤的50%左右。目前临床上IV型神经胶质瘤是恶性程度最高的脑部肿瘤，至今无法治愈 ADDIN EN.CITE EndNoteCiteAuthorTanaka/AuthorYear2013/YearRecNum1/RecNumDisplayText[1]/DisplayTextrecordrec-number1/rec-numberforeign-keyskey app=EN db-id=wdfrpf0t6ete24exef3vzxfvsepxvv505t0z1/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorTanaka, S./authorauthorLouis, D. N./authorauthorCurry, W. T./authorauthorBatchelor, T. T./authorauthorDietrich, J./author/authors/contributorsauth-addressStephen E. and Catherine Pappas Center for Neuro-Oncology, Boston, MA 02114, USA./auth-addresstitlestitleDiagnostic and therapeutic avenues for glioblastoma: no longer a dead end?/titlesecondary-titleNat Rev Clin Oncol/secondary-titlealt-titleNature reviews. Clinical oncology/alt-title/titlesperiodicalfull-titleNat Rev Clin Oncol/full-titleabbr-1Nature reviews. Clinical oncology/abbr-1/periodicalalt-periodicalfull-titleNat Rev Clin Oncol/full-titleabbr-1Nature reviews. Clinical oncology/abbr-1/alt-periodicalpages14-26/pagesvolume10/volumenumber1/numberkeywordskeywordAntineoplastic Agents/*therapeutic use/keywordkeywordBrain Neoplasms/diagnosis/*therapy/keywordkeywordCombined Modality Therapy/keywordkeywordGlioblastoma/diagnosis/*therapy/keywordkeywordHumans/keywordkeywordPrognosis/keywordkeywordSignal Transduction/*drug effects/keyword/keywordsdatesyear2013/yearpub-datesdateJan/date/pub-dates/datesisbn1759-4782 (Electronic)#xD;1759-4774 (Linking)/isbnaccession-nuaccession-numurlsrelated-urlsurl/pubmedurl/related-urls/urlselectronic-resource-num10.1038/nrclinonc.2012.204/electronic-resource-num/record/Cite/EndNote[ HYPERLINK \l _ENREF_1 \o Tanaka, 2013 #1 1]。多形性胶质母细胞瘤（Glioblastoma Multiforme,?GBM） 起源于脑部神经胶质细胞，成年脑癌患者中约80%为浸润性的星形细胞瘤。由于该肿瘤是HYPERLINK /view/4773521.htm \t _blank浸润性生长物，其和正常 HYPERLINK /view/4224866.htm \t _blank 脑组织没有明显的界限，因此难以被完全切除或根本不能手术。血脑屏障的存在，又使得 HYPERLINK /view/1535215.htm \t _blank 化学药物和一般抗肿瘤的中药难以发挥疗效。该肿瘤细胞对放疗亦不甚敏感