MRI-DOT.ppt

1.hybrid MRI-DOT system;The system contains eight 785nm wavelength laser sources with eight optical detectors in a fan beam geometry. 该系统包含八个785nm波长的激光源，在一个扇形束几何里有8根光纤探测器 The laser diode was modulated at 100 MHz using a network analyzer (Agilent Technologies, Palo Alto, CA).激光二极管被调制在100MHz使用网络分析仪 An 8x32 fiber optic switch (Dicon Fiberoptic, GP700) was used to multiplex the modulated laser to eight source fibers.一个8X32光纤开关用于调制的激光多路复用到八个源纤维 Eight photomultiplier tubes (R7400U-20 Hamamatsu, Japan) were connected with eight detector fibers to deliver transmitted light from the animal. 八个光电倍增管连接有八个检测器纤维从动物递送的透射光 An 8-channel dynamic signal acquisition board (National Instruments) was used for parallel acquisition for eight detectors for each source at the same time, yielding sixteen seconds acquisition time for each diffuse optical tomography frame.8通道的动态信号采集板用于并行采集八个探测器为每个源的同时，得到16秒采集时间为每个扩散光学断层扫描帧。;ISOL Technology MR console was used here with a 4T magnet with a custom-designed birdcage type RF coil which was built into the DOT interface. ISOL技术MR控制台这里使用了4T磁铁定制设计的鸟笼式射频线圈这是建立在DOT接口 Twenty meters long fiber optic cables passed through a waveguide from the RF-shielded MRI room to the control room where the DOT detection unit and data acquisition hardware was located 二十米长的光纤电缆从设有DOT检测单元和数据采集硬件的RF-屏蔽核磁共振室至控制室通过波导 We used 15ms echo time, 90 degrees flip-angle, 120 mm field of view, 4 mm slice-thickness,150 ms repetition time and 128 x 128 pixels resolution.我们使用15ms的回波时间，90度翻转角，视120毫米场，4毫米切片厚度，150毫秒的重复的时间和128×128像素的分辨率。 The temporal resolution of DCE-MRI was 20.5 seconds. DCE-MRI的时间分辨率是20.5秒 ;2.image reconstruction;The reduced scattering and the absorption coefficients of the medium are represented as μ s ′ (mm -1 ) and μ a (mm -1 ). μ s ′ (mm -1)表示介质中减少的散射系数， μ a (mm -1 )表示介质中减少的吸收系数。 The modulation frequency and the speed of light in the tissue are represented by ω and c n . ω表示调制频率，Cn表示光在组织中的速度 The inverse problem was solved by Levenberg-Marquardt method： Where ε is