移植免疫2013资料.pptVIP

中南大学湘雅医学院免疫教研室田 伟 博士， 教授;Allografts: transplants from a genetically unrelated donor of the same species. Allogeneic transplantation: the last resort for the treatment of chronic organ failure. the major complication post-transplantation is rejection. Rejection occurs in almost all transplant recipients, to varying degrees. ;E.D.Thomas;;Antigen independent mechanisms;Peritransplant injury induces chemokines that increase inflammation and immunity;Content;;器官移植排斥的本质：一种免疫应答过程。 自体/同系移植不排斥，同种异体移植排斥。 首次排斥（术后10-13天）,再次排斥（6-8天）。 再次移植无关个体皮肤，排斥时间为10-13天。 移植到裸鼠，排斥（-）；输入无关个体T细胞， 则排斥（+）。;第1节 同种异体移植排斥的机制;Types of transplantation;Skin from an inbred mouse grafted onto the same strain of mouse;6 months;Immunogenetics of graft rejection;Histocompatibility and graft survival;一.引起同种移植排斥反应的抗原;HLA antigens: The HLA genes represent the most polymorhic genetic system in humans. Usually multiple alleles at the classical HLA loci exist in the human population . Non-synonymous substitution results in allotype antigen.;Simplified map of the HLA region;IMGT/HLA??Sequence Database ?Statistics Allele Information HLA Class I Alleles: 1,156 HLA Class II Alleles: 712 HLA Alleles: 1,868 Other Alleles: 67（Including 56 MICA alleles);Polymorphism in MHC Class I genes;Polymorphism in MHC Class II genes;次要组织相容性抗原（minor Histocompatibility antigens, mH抗原） 与性别相关的mH抗原 Y染色体基因编码的H-Y抗原. 非Y染色体连锁的mH抗原(HA-1~HA-5) ;Identification of the Minor Histocompatibility Antigen HA-1 Correlates with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. Derived from nonapeptide of an allele of the KIAA0223 gene.; KIAA0223 gene forms a diallelic system. The two alleles differ in: Two nucleotides A single amino acid.;VLHDDLLEA is encoded by an allele HA-1H. VLRDDLLEA is encoded by an allele HA-1R.;HA-1 (HA-1H) has a population frequency of 69%. HA