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PresentandFutureofMedicalImagingPhysics包尚联ShanglianBao北京大学医学物理和工程北京市重点实验室BeijingKeyLabofMedicalPhysicsEngineering北京大学肿瘤物理诊疗技术研究中心TheResearchCenterofTumorDiagnosisandTherapeuticalPhysicsbao@2016-12-91ICMIP-2013沈阳BasicdisciplinesofhealthprotectionPhysics，ChemistryinformaticsSafeguardhumanhealthSolveproblemfromoriginalrequirement2016-12-9ICMIP-2009沈阳2Goal:getenoughVivostateinformationbyNon-invasivemedicalimagingmeansincludingmolecular，cell，organandsystemformorphological,physiologicalandpsychologicalinformationinprecise,accuracy2016-12-9ICMIP-2013沈阳3PhysicsEngineeringofMedicalImagingMedicalImagingPhysicsPrincipleandprototypedeviceMedicalImagingEngineeringIndustrydeviceandproductionBothdoapplicationinclinicaldiseaseDiagnosisdiseasetherapeuticsDatatreatmentandanalysisVerificationandguarantee4MajorModalitiesX-rayImaging(animalhumanimaging)Planer:DR,CRTomography:spiralCT,ConeBeanCTNMI(animalhumanimaging)SPECT:combiningwithCTPET:combiningwithCTMRI(animalhumanimaging)Middle，highExtrahighfieldsystem;UltrasoundI3D,4DimagingGeneralandspecial2016-12-9ICMIP-2013沈阳4EssentialTaskAllplacestimesneedtoextendthehumaneyecapability，AccompanyinghumandevelopmentAfterMacroscopicinformation，Microscopicinformationmoreimportant；Aftermorphology，physiologymoreimportant；Aftereyevisibleinformation,eyeinvisibleinformationismoreimportant,includingphysiologyandpsychology.2016-12-9ICMIP-2013沈阳52016-12-96FrontDirection:MolecularImagingPermanenttopic：NewgeneticmaterialandproteinsAccompanyingtheprogressofmankindRevealingessentialpathologicalreasonVeryearlier(sufficienttimetoadjustandtreatment)ICMIP-2013沈阳2016-12-97mRNADNARNA酶的合成和活性调控物转运蛋白RNA结合物报告探针报告基因DNAAATglut4代谢产物MAb激素配体缩氨酸DNA合成物+othermoleculesAllindynamicaland3DdistributionICMIP-2013沈阳TwomostimportantmoleculesNewgeneticmaterialHumanevolutionfasterthanbefore(naturalandartificial)Nature：changesonbiodiversity,climaticconditions,foodchain,speedofmixedracegeneArtificial：Newgeneticmodificationofplantsandanimals，evenhumanProteinsHumanProgressrelyonproteinsan
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