血必净对有菌肾盂灌注液所致猪SIRS和肾脏病理改变的影响.pdfVIP

目 录 一、中文摘要 ······························································· 1 二、英文摘要 ······························································· 3 三、正文 ····································································· 5 1、前言 ····································································· 5 2、材料与方法 ···························································· 7 3、结果 ····································································· 13 4、讨论 ····································································· 25 5、结论 ····································································· 32 6、参考文献 ······························································· 33 四、综述 ····································································· 37 五、主要缩略词表 ························································· 48 六、攻读硕士学位期间发表的论文 ···································· 49 七、致谢 ····································································· 50 万方数据 血必净对有菌肾盂灌注液所致猪 SIRS 及肾脏病理改变的影响 硕士研究生：杨 帆 导 师：陈 仙 中文摘要 目的：本实验拟利用猪自体盲肠内容物加入肾盂冲洗灌注液中建立有菌肾盂灌 注液所致猪 SIRS 模型，并观察血必净注射液对有菌肾盂灌注液所致猪 SIRS 及肾脏 病理学改变的影响并探讨其作用机理，为临床 PCNL 术后并发 SIRS 的治疗提供实验 及理论依据。 方法：选用健康家猪 15 只，所有实验动物随机分成假手术组(Sham 组)、模型 组(Model 组)和血必净治疗组(XBJ 组)，每组 5 只，每组所有动物按时间点又分为术 前、术后 0h、术后 6h、术后 12h 和术后 24h 5 个时间观测点。其中，Model 组采用猪 自体盲肠内容物加入肾盂冲洗灌注液中，建立肾盂灌注冲洗并发 SIRS 猪模型；Sham 组只开腹，翻动肠管，不进行肾盂灌注冲洗液污染肠内容物操作，其余过程同 Model 组；XBJ 组在造模后用血必净注射液