核心蛋白聚糖怎样抑制中枢神经系统的瘢痕形成.docVIP

核心蛋白聚糖治疗脊髓损伤 核心蛋白聚糖：怎样抑制中枢神经系统的瘢痕形成？ 中枢神经系统瘢痕的周围环境可能会抑制轴突生长，因为生长抑制性硫酸软骨素蛋白聚糖、脑信号和肝配蛋白会通过反应性胶质化星形胶质细胞和软脑膜成纤维细胞迁移到分泌到伤口。中枢神经系统髓鞘衍生轴突生长抑制剂Nogo，髓鞘相关糖蛋白和少突胶质细胞源性髓鞘糖蛋白也会随着神经纤维髓鞘下降被释放到病变周围。 目前已开发的促进中枢神经系统轴突再生策略，包括消除抑制分子，外源性神经营养因子疗法，神经组织移植，干细胞治疗，基因治疗，生物材料移植修复受损伤的脊髓组织，电刺激瘫痪肌肉等，但这些治疗方法目前还很难在临床治疗中得到实现。来自英国伯明翰大学的Zubair Ahmed教授在本文中回顾了使用核心蛋白聚糖对抑制中枢神经系统急性瘢痕形成和使脊髓损伤后成熟瘢痕溶解的作用，并讨论了相应减少轴突生长抑制配体而有利于脊髓轴突再生的策略。相关研究内容发表在2014年9月第18期《中国神经再生研究（英文版）》杂志上。 Article: Decorin treatment of spinal cord injury by Maryam Esmaeili, Martin Berry, Ann Logan, Zubair Ahmed Neurotrauma Research Group, Neurobiology Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, UK Esmaeili M, Berry M, Logan A, Ahmed Z. Decorin treatment of spinal cord injury. Neural Regen Res. 2014;9 18 :1653-1656. 欲获更多资讯：Neural Regen Res Decorin treatment of spinal cord injury The scarring response after a penetrant central nervous system CNS injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the CNS, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, Dr. Zubair Ahmed from University of Birmingham, UK discuss the potential of using Decorin to antagonise scarring in the CNS. The relevant study has been published in the Neural Regeneration Research Vol. 9, No. 18, 2014 . Article: Decorin treatment of spinal cord injury by Maryam Esmaeili, Martin Berry, Ann Logan, Zubair Ahmed Neurotrauma Research Group, Neurobiology Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, UK