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临床实践指南更新 CONFIDENTIAL Document Date This report is solely for the use of client personnel. No part of it may be circulated, quoted, or reproduced for distribution outside the client organization without prior written approval from McKinsey Company. This material was used by McKinsey Company during an oral presentation; it is not a complete record of the discussion. This document provides an outline of a presentation and is incomplete without the accompanying oral commentary and discussion. Conclusions and/or potential strategies contained herein are NOT necessarily endorsed by Pfizer management. Any implied strategy herein would be subject to management, regulatory and legal review and approval before implementation Unit of measure * Footnote Source: Source Company Confidential and Proprietary Information – For Internal Discussion Purposes Only – Do Not Disseminate Without Approval Unit of measure * Footnote Source: Source Company Confidential and Proprietary Information – For Internal Discussion Purposes Only – Do Not Disseminate Without Approval CONFIDENTIAL Document Date This report is solely for the use of client personnel. No part of it may be circulated, quoted, or reproduced for distribution outside the client organization without prior written approval from McKinsey Company. This material was used by McKinsey Company during an oral presentation; it is not a complete record of the discussion. This document provides an outline of a presentation and is incomplete without the accompanying oral commentary and discussion. Conclusions and/or potential strategies contained herein are NOT necessarily endorsed by Pfizer management. Any implied strategy herein would be subject to management, regulatory and legal review and approval before implementation 产品特点 受体: SRI,DRI,σ1 5-HT再摄取抑制能力强 呈线性药代动力学特点 青少年和老年人的药代参数与18-65岁成年人无明显差异 食物对舍曲林的生物利用度无明显影响 对CYP450酶影响小，药物相互作用少 发表于2009年3月的 《国际临床精神药理学》杂志 使用Pubmed进行相关医学文献搜索； 搜索内容为有关舍曲林适应症（美国） 的RCT研究，包括比较研究。 2 老年患者 8 躯体疾病共病 9