细胞与肠粘膜免疫途径成稿要点.doc

细胞工程结业论文 学号： 细胞与肠粘膜免疫途径 学生姓名： 指导教师： 所在学院：生命科学技术学院 专 业：生物科学 中国·大庆 2013年 6 月 细胞与肠粘膜免疫途径 摘要：肠道粘膜不仅是机体消化、吸收营养物质的场所, 而且还具有重要的免疫功能。分泌型免疫球蛋白A、上皮内淋巴细胞、微皱褶细胞和细胞因子, 共同组成肠道粘膜免疫系统,肠道免疫系统由大量弥散分布在肠黏膜上皮内和固有层的免疫细胞和免疫分子、以及诸如peyer’s patches（PP）等肠相关性淋巴组织等组成。小肠PP结为肠黏膜免疫主要诱导部位，肠黏膜上皮和固有层为主要效应部位。B细胞、T细胞在PP结诱导后，分化、成熟，并移行到黏膜效应部位，发挥免疫效应功能。另外，本文着重介绍肠粘膜免疫中M细胞的功能。 关键词: 肠粘膜免疫途径；M细胞；粘膜免疫 Cells and intestinal mucosal immune pathway Abstract: the intestinal mucosa is not only the bodys digestion, absorption of nutrients in the place, but also have important immune function. Secretory immunoglobulin A, intraepithelial lymphocytes, microfold cells and cytokines, composed of intestinal mucosal immune system, intestinal immune system consists of a large number of dispersed in intestinal intraepithelial and lamina propria of the immune cells and molecules, such as s patches and Peyer (PP) composition gut associated lymphoid tissue. Intestinal PP node for intestinal mucosal immunity induced mainly site, intestinal mucosal epithelium and lamina propria as main effect site. B cells, T cells in the PP node after the induction, differentiation, maturation, and moved to the mucosal effector sites, immune effector function. In addition, this paper focuses on M cells of intestinal mucosal immunity function. Keywords: intestinal mucosal immune pathway; M cell; mucosal immunity 目 录 前言 1 ………………………………………………...1 1.1 诱导部位.......................................................................................1 1.2效应部位………………………………………………………………..2 2 肠黏膜免疫系统抗原的摄取、处理和递呈…………………………..2 2.1 M细胞对抗原的转运…………………………………………………..2 2.2抗原递呈细胞对抗原的摄取、处理和递呈…………………………3 3 sIgA在肠粘膜免疫中的作用…………………………………………..3 3.1抗感染作用……………………………………………………………..3 3.2抗肿瘤作用……………………………………………………………..3 3.3 抗过敏和其它作用…………………………………………………….4 4 肠粘膜免疫的M细胞介绍……………………………………………..4 4.1 M细胞的来源结构与分化…………………………………………….4 4.2 M细胞的表面分子…………………………………………………….4 4.3 M细胞的功能 ………………………………………………………….5 4.4 M细胞的应用………………………………………………………….5 5 结语与讨论………………………………………………………………5