兔人工气管移植后成活时间与C-反应蛋白的相关性.docVIP

兔人工气管移植后成活时间与C-反应蛋白的相关性 姚? 佳1，李晓军2，崔晓海2，赵? 阳3，张? 靖2，李? 刚2，曹培龙4 1山西大医院消化内科，山西省太原市? 030001；西安交通大学医学院第一附属医院，2胸外二科，4病理科，陕西省西安市? 710061；3西安交通大学医学院第二附属医院肿瘤外科，陕西省西安市? 710004 Correlation of survival time and C-reactive protein after artificial tracheal replacement in rabbits Yao Jia1, Li Xiao-jun2, Cui Xiao-hai2, Zhao Yang3, Zhang Jing2, Li Gang2, Cao Pei-long4 1Department of Gastroenterology, Shanxi Dayi Hospital, Taiyuan 030001, Shanxi Province, China;?2Second Thoracic Department,?4Department of Pathology, First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China;?3Department of Oncosurgery, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China 摘要? 背景：研究证实C-反应蛋白在炎症发生及组织损伤时迅速升高，并能提示炎症反应程度。 目的：分析实施带支撑环的聚四氟乙烯人工气管替代实验兔颈段气管后成活时间与C-反应蛋白的相关性。 方法：用带支撑环聚四氟乙烯人工气管替代实验兔颈段气管，重建气道，观察实验兔气管移植后生存时间，以及实验兔气管移植后第1-7天血清C-反应蛋白的变化。利用简单线性回归分析二者之间的关系。 结果与结论：血清C-反应蛋白水平的变化和实验兔生存时间之间呈简单线性相关。生存时间小于13 d的实验兔C-反应蛋白与气管移植后天数呈正相关升高趋势，而生存时间大于13 d的实验兔C-反应蛋白呈负相关降低趋势。正相关兔和负相关兔中位生存时间及95%可信区间 CI 分别为：10 d 95%CI?8.614-11.386 d 和27 d 95%CI?23.970-30.030 d 。负相关样本的生存率明显高于正相关样本 χ2 29.364，P? 0.01 。结果证实实验兔气管移植后生存时间的延长与C-反应蛋白水平的降低有关。 中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程 全文链接： 关键词?：?实验动物；?组织构建；?气管移植；?气管肿瘤；?肺炎；?C-反应蛋白； Abstract： BACKGROUND:C-reactive protein has been shown to rapidly increase during the occurrence of inflammation and tissue injury, and can indicate the degree of inflammatory reaction. OBJECTIVE:?To analyze the correlation between survival time and C-reactive protein in rabbits after transplantation of polytetrafluoroethene artificial trachea with support ring. METHODS:?The cervical trachea of rabbits was replaced by polytetrafluoroethene artificial trachea with support ring. Survival time of the rabbit, and the changes in serum C-reactive protein at 1-7 days after transplantation were observed. Linear regression was used to assess the univariate association betwe