2014ERSATS重度哮喘指南解读.pptVIP

Definition Four criteria Mechanism Phenotype Defined as the composite, resulting from interaction between its genetic make-up and environmental influences; Relatively stable, but not invariable with time; Phenotyping integrates biological and clinical features, ranging from molecular, cellular, morphological and functional to patient-oriented characteristics. The goal is to improve therapy ! Phenotypes and clusters SARP cluster classification Adult ①Early onset atopic asthma; ②Later onset obese group of primarily older females ; ③Later onset but long duration ve