Copyright2012ElsevierInc.Allrightsreserved.pptVIP

Copyright ? 2012 Elsevier Inc. All rights reserved. Figure 9.17 Left panel, cell-mediated release of VEGF from hydrogels made from 4-armed PEG chains end-functionalized with vinyl sulfone VS , conjugated with a cell adhesive peptide and VEGF, and cross-linked with a MMP-2 cleavage site peptide. VEGF could be released from this gel by either MMP-mediated degradation or plasmin-mediated cleavage of the matrix anchor. Right panel, A–C, chorioallantoic membrane CAM assay for angiogenesis. A Control hydrogel without VEGF does not induce angiogenesis. B Hydrogel with freely diffusible VEGF in