分子生物学原理(癌症)详解.pptVIP

v-Src protein is a constitutively active mutant form of c-Src protein, a protein-tyrosine kinase In cells containing an integrated RSV genome: a. v-src transcribed at inappropriately high rate level, b. The unregulated activity of v-Src protein causes continuos and inappropriate phosphorylation of target proteins. V-src is a dominant gain-of-function mutant of c-src, since v-src can induce cell transformation in the presence of the normal c-src proto-oncogene. Many other oncogenes derived from cellular proto-oncogenes have been found in different retr