对我国耳鸣治疗文献的循证医学评价(精选).docVIP

对我国耳鸣治疗文献的循证医学评价 作者：王洪田 【摘要】 目的　复习我国近5年来有关耳鸣的文献资料，分析耳鸣的诊治现状。方法　在中国生物医学文献数据库（cmcc）以耳鸣和治疗为关键词检索2002年 ～ 2006年发表的耳鸣文献。依据国际循证医学标准，在中国期刊网医学专题全文数据库（）下载全文进行逐篇分析。结果　以耳鸣为关键词共检出758篇文章，再用治疗为关键词二次检出496篇，以耳鸣为第一治疗目的的文献204篇，中医药治疗耳鸣文献多达176篇（86.3%）。说明耳鸣治疗例数的186篇（91.2%），共治疗患者9 731例。其中， 设有对照试验的75篇（40.3 %），符合临床随机对照试验（randomized controlled trials ，RCT）的53 篇（28.5 %），应用随机分组的文献62篇（33.3%），仅有19 篇（10.2%）进行了组间均衡性检验；许多文献用常规药物治疗耳鸣，但常规药物包括的内容却各不相同；无1 篇使用真正的安慰剂作对照，仅有2篇文献采用双盲方法，其它均为开放实验；无多中心的协作研究；仅17 篇有不良反应记录，3篇文献涉及不良事件的干预措施，7篇文献说明了退出及失访情况，6 篇有随访记录，最长随访3年。结论　我国治疗耳鸣的文献很多，尤其中医药治疗耳鸣的文献更多，但绝大部分都没有严格按照随机、双盲、对照、多中心的原则进行实验设计，更没有统一的疗效标准，使得结果与结论不够客观、可靠，并且缺乏可比性，影响了国内外学术交流。我国耳鸣治疗研究论文的质量有待提高。 【关键词】 耳鸣;　治疗;　随机对照试验;　期刊论文 Evaluation of the clinical studies of tinnitus treatment in China WANG Hong-tian, ZHAI Suo-qiang, HAN Dong-yi, YANG Wei-yan Institute of Otorhinolaryngology, Department of Otorhinolayngology Head and Neck Surgery, Chinese PLA General Hospital , Beijing 100853 , China Correspondig author: Wang Hong-tian, Email: wht301@263.net 　　【Abstract】 Objective　To summarize and evaluate the current situation on tinnitus studies in China by retrospective review of the articles appeared in Chinese journals in the past 5 years. Methods　The terms of tinnitus and therapy were used to search all of the papers on the Chinese biomedicine literature data base and Chinese journal net from 2002 to 2006. All of the papers were analyzed according to the standards of evidence based medicine. Results　One hundred and eighty-six papers were fitted in with the keywords. A total of 9731 patients were treated. Seventy-five papers were controlled studies. Fifty-three were randomized controlled trials （RCT）. Sixty-two used randomized methods to divide patients into groups. Base-line statistics studies were analyzed in 19 trials. Most studies used regular medicine or methods to treat patients with tinnitus but the regular medicine or methods were very different from ea