(高血压).ppt

Figure of cardiac glycosides and Na+,K+/ATPase action Amrinone (氨力农) Amrinone is the first PDEI drug in clinical use in 1978. (1) The Development of NO donor drugs Organic nitrates have dominated the treatment of acute angina over 100 years after the antiaginal effect of amyl nitrite (亚硝酸异戊酯) was first observed in 1857. Although the introduction of the calcium channel blockers and the β-adrenergic blockers as antianginal agents has expanded the physician’s therapeutic arsenal, organic nitrates are still the class of choice to treat acute anginal episode. Chemistry of nitrates Organic nit