戴安公司4-MSQ新型台式液质联用仪(PPT).pptVIP

Fall Seminar 2000 MSQ?: 新型台式液质联用仪 C. Loran戴安公司, Sunnyvale, CA, USA MSQ 简介 MSQ 的尺寸 特点 高灵敏度 (10X previous) 电喷雾(ESI) and APCI 50-2000 质量范围 (标准) 专利锥清洗技术 Cone Wash 新型M-Path低噪源设计 Simple clip-in FastLoc? probes 可扩展低质量选择 方便操作… 易于方法建立 性能检查 调整简单 流畅的设计 易于使用… 无须工具维护的吹扫清洗源 稳固… 专利锥清洗技术 隐蔽的溶剂输送线 直观的摆动定位 电喷雾(ESI)管口描述 M-Path? 流路示意图 选择性… M-Path? 流程图 通用接口技术 大气压化电离API 电喷雾 (ESI) 大气压化学电离 (APCI) 流速 (无分流) 10 μL to 2 ml for ESI 200 μL to 2 ml for APCI 加热辅助 – 气动喷雾 环境温度--- 650°C 氮气喷雾 450 L/hr ESI/APCI 切换 Fast Loc? ESI 和 APCI 探针 切换方便快捷 自动连接气源和动力源 切换时间 1 minute FastLoc? Probes 牢固,自锁设计 所有不锈钢/陶瓷结构减少化学背景 User replaceable capillaries 增强的离子化控制 ESI 尖端电压控制 (TRV) 流动相电导变化电压校准 梯度洗脱时保持稳定的色谱基线 APCI – 电晕电流强度控制 (CCC) 0.1 to 50 μA regulated discharge current in 0.1 μA steps for improved optimization long and short term ionization stability is maintained as corona tip contamination increases 改进质谱响应 Low Mass Option 高氯酸盐样 线 性… 利血平 1pg – 10 ng 灵敏度… Four 1pg injections of diphenhydramine 质谱方法编辑 扫描功能模式改变 选择性, 特异性, 灵敏度 Full scan TIC plus 5 simultaneous SIM plus full scan spectrum… from one analysis 同步链接 紫外和质谱数据 馏分收集报告 仪器特性 LC and Mass ystems The source is extremely clean, with no exposed wires, jumpers, lines, or connections. The alignment of the probes is automatic, and the source can be easily cleaned by rinsing and wiping. It has an internal drain so that excess liquid is diverted to the waste(illustrate) Routine maintenance of the MS requires no tools, with easy access to the entrance cone and with the removal of two thumbscrews the exit cone and focusing RF lens. In any LC/MS system, it is necessary to balance the need to have a vacuum (high mean free path = increases the chance of an ion travelling from a point of generation, being scanned by the quadrupole and being detected without the possibility of a collision) with the need to have a high number of sample ions transmitted through the MS system. This is accomplished using a small orifice (hole) which separates the atmospheric part of the