拜耳Maxson.ppt

Hazard and Operability Studies in Solid Dosage Manufacture PQRI Risk Management Workshop January 31, 2005 Neil L. Maxson, CSP Hazard and Operability Studies in Solid Dosage Manufacture Bayer Example Hazard and Operability Studies in Solid Dosage Manufacture Hazard and Operability Study Diverse group of experts applying a defined approach to proactively identify and analyze hazards and operability problems Goal is to provide protective measures to prevent incidents, assure product quality and promote process efficiency Team based approach critical Several specialists with different backgrounds can interact and identify more problems when working together than when working separately and combining their results. Hazard and Operability Studies in Solid Dosage Manufacture Benefits Prevent injuries Prevent environmental damage Prevent damage to equipment and property Foster community and public relations Enhance process operability, reliability and efficiency Advance product quality Up to date process documentation Common understanding of details of process Bayer PHA Process Dust and Powder Hazards Hazard Property, condition, circumstance, etc. that, under the right situation, can lead to an event with potentially unfavorable outcome or consequence You need to know specifics about the materials you handle Powders and Dusts present varied and wide ranging challenges Combustibility Propensity to burn or explode Many powder materials will burn; explode when cloud in air; organics particular concern Degree of hazard related to particle size Need ignition source Heat sources Flames Static Electricity Resources Several related National Fire Protection Association Guidelines Center for Chemical Process Safety (CCPS) Guideline Books; “Safe Handling of Powders and Bulk Solids” Consultants Dust and Powder Hazards Powders and Dusts present varied and wide ranging challenges Instability Tendency to vigorously decompose, polymerize, self-react, oxidize Generally exothermic reacti