评估神经导管修复周围神经损伤有效性的新型归一化法.docVIP

评估神经导管修复周围神经损伤有效性的新型归一化法 美国史蒂文斯理工学院化学、化学生物学及生物医学工程学系Xiaojun Yu团队研究人员已经开发出了一种新的评估修复周围神经损伤的神经导管的性能规范化的标准，相对再生率（RRR），此方法可以分别对不同长度神经损伤，附加因素及恢复时间等进行对比分析。 神经导管在引导损伤神经中起着结构导向作用，可桥接损伤神经，促进受损部位的功能恢复。神经缺损长度对神经导管研究提出挑战。修复缺损长度超过10mm的大鼠坐骨神经所需要的神经导管需要有较大的截面面积和辅助因素，如添加生长因子，细胞，蛋白质，及适合的纳米纤维。神经导管的生物材料研究已有相关的文献报告，然而，比较神经导管修复恢复时间及有效性的评估方法还未见报道。如何定量的评估神经导管的有效性是神经导管研究的另一个重要方面。 神经导管的终极目标是要开发出与自体移植结果相媲美的植入物。“相对再生比”来源于用于规范自体移植物修复神经损伤长度和神经传导速度数据的最优拟合线。作者实验已证明通过对相对再生比的计算，可以得出神经导管相对自体移植物的性能。该研究发表在《中国神经再生研究（英文版）》（2014年9卷22期）。研究人员可根据此方法结合趋化性和趋触性来评估损伤修复的效果，减少实验所需时间和资源。 Article: Evaluating nerve guidance conduits for peripheral nerve injuries: a novel normalization method? by Munish B. Shah, Wei Chang, Xiaojun Yu (Department of Chemistry, Chemical Biology, and Biomedical Engineering Stevens Institute of Technology, Hoboken, NJ 07030 USA) Shah MB, Chang W, Yu XJ. Evaluating nerve guidance conduits for peripheral nerve injuries: A novel normalization method. Neural Re- gen Res. 2014;9(22): 1959-1960. 欲获更多资讯： HYPERLINK /Neural Re- gen Res A Novel Method for Evaluating Nerve Guidance Conduits for Peripheral Nerve Injuries SUMMARY Any nerve injury outside the brain and spinal cord is classified as a peripheral nerve injury (PNI) and can ultimately lead to paralysis. The fabrication of nerve guidance conduits (NGCs) can aid and induce nerve regeneration to alleviate potentially disabling conditions. A novel method to evaluate and compare NGC performance allows researchers and clinicians to fabricate NGCs that can induce complete nerve regeneration and fully restore function for injured nerves. NEWS RELEASE Researchers at the Stevens Institute of Technology in Hoboken, NJ, led by Dr. Xiaojun Yu, have developed a novel normalization standard, relative regeneration ratio (RRR), to evaluate the performance of NGCs. This method allows the comparison of NGCs in different conditions such as various gap lengths of nerve injury, additives, and recovery times. NGCs serve as physical guidance structures for a