Direct and Inverse bioelectric problems.ppt

Direct and Inverse bioelectric problems Presented by Chao Shen George Landon Cheng dong Li University of Kentucky Outline Introduction of bioelectricity and bioelectric problems. Direct and inverse problems Model construction and mesh generation example(EEG) History of research on bioelectric field problems What is bioelectricity? The origins of bioelectricity lie within cell membranes, which maintain a small potential difference between the interior and exterior of each cell. Fluctuation of this potential acts as a signaling mechanism that permits nerves to interact, muscles to contract, and communication to occur over the whole body. Bioelectric field problems Bioelectric field problems can be found in a wide variety of biomedical applications which range from single cells, to organs, up to models which incorporate partial to full human structures To diagnose tissue as either healthy or diseased, bioelectric signals from the tissue have to be recorded. Measurement of Bioelectricity (1) Noninvasive Measurement (2) Invasive Measurement Applications The solutions to bioelectric problems have applications to defibrillation studies, detection and location of arrhythmias, and localization and analysis of spontaneous brain activity in epileptic patients, etc. Our focus EEG (electroencephalography) ECG (electrocardiography). Early ECG machine, circa, 1911 Poissons and LaplacesEquation Poissons Equation Laplaces equation Bioelectric Volume Conductors A general volume conductor can be defined as a region of volume, , which has conductivity, , and permitivity, , in which resides a source current, , where the V signifies per-unit volume. Solving a volume conductor problem means finding expressions for the electric, , and potential, , fields everywhere within the volume, , and/or on one of the bounded surfaces, . continue Direct problems The direct pro