EfficacyEvaluationinAcneClinicalTrials.docVIP

Efficacy Evaluation in Acne Clinical Trials An Outline Re-visit choice of the primary endpoint for analysis: change score, relative change and lesion counts (statistical viewpoint). Statistical analysis for efficacy evaluation: Analysis units: original vs. transformed data Analysis methods Gain in power using subject’s repeated assessments in lieu of the final assessment. Do efficacy findings (whether based on change, counts or IGE) vary by baseline severity? I. Re-visit choice of primary endpoint for analysis: change score, relative change and lesion counts (statistical viewpoint):