Adaptive Immune Response.ppt

Adaptive Immune Response General Introduction of Adaptive Immune Response Definitions: A collective and coordinated response to the introduction of foreign substances in an individual mediated by the cells and molecules of immune system Locations where immune response develops 1. Immune response develops in the secondary lymphoid organs 2. Antigens are concentrated in the draining lymphoid organs 3. lymphocyte recirculation Classification of Adaptive Immune response T cell-mediated immune response-cellular immunity B cell-mediated immune response-humoral immunity T cell-mediated immune response The T cell-mediated immune response can be divided into three stages, i.e., antigen recognition; expansion and differentiation and effector Stage The recognition of T cll to Ag T cell recognise the MHC-Ag complex on APC CD4+Th cells recognize the MHC II-Ag complex on APC CD8+ CTLs recognize the MHC I-Ag complex on APC The CDR1 and CDR2 recognize the MHC molecules of MHC-Ag complex（CDR1和CDR2识别MHC分子） CDR3 recognize the Ag peptide of MHC-Ag complex.（CDR3识别抗原肽） This is called double-recognition（双识别） After TCR recognize the MHC-Ag complex, the CD4 OR CD8 will bind to the Ig-like domain of MHC. CD4 bind to β2 domain of MHC II, CD8 bind to α3domain of MHC I （TCR识别MHC-Ag复合物后，CD4，CD8将与MHC的Ig样功能区结合，CD4结合MHCII分子的β2， CD8结合MHCI分子的α3 ） AMs are involved in antigen recognition by T cell Formation of immunologic synapses Stage of activation, proliferation and differentiation 1. Activation Activation of CD4+ T cell Generation of the first signal-specific signal Generation of the second signal- co-stimulatory signal The TCR-CD3 complex of T cell recognize and bind to MHC-Ag complex, through the CD3 molecule deliver the Ag specific signal into the intracellular-----The first signal of T cell activation （T细胞上TCR-CD3复合体识别和结合MHCII-Ag复合体后，通过CD3分子将抗原特异性信号传入细胞内----T细胞活化的第一信号） The CD28/CTAL-4 of T cell will contact with CD86/CD80 and del