EffectsofLY393558(+LY,30mgkg1day1)and.pptVIP

Effects of LY393558 +LY, 30 mg kg?1 day?1 and citalopram +Cit, 20 mg kg?1 day?1 on development of right ventricular systolic pressure RVP A, D; n 5–9 , pulmonary vascular remodelling B, E; n 4–5 and right ventricular hypertrophy RVH C, F; n 5–9 in WT A–C and SERT+ D–F mice. Ian Morecroft et al. Cardiovasc Res 2010;85:593-603 Published on behalf of the European Society of Cardiology. All rights reserved. ? The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org. Effects of LY393558 +LY, 30 mg kg?1 day?1 and citalopram +Cit, 20 mg kg?1 day?1 on development of right ventricular systolic pressure RVP A, D; n 5–9 , pulmonary vascular remodelling B, E; n 4–5 and right ventricular hypertrophy RVH C, F; n 5–9 in WT A–C and SERT+ D–F mice. Mice were subjected to 2 weeks of hypoxia. Data are mean ± SEM. ***Value significantly greater than corresponding value in vehicle treated normoxic mice P 0.001 . ?Value significantly less than corresponding value in vehicle treated mice ?P 0.05, ??P 0.01,???P 0.001 . ?Value significantly greater than corresponding value in LY393558 treated mice ?P 0.05, ???P 0.001 . §Value significantly greater than corresponding value in WT vehicle treated mice §P 0.05, §§P 0.01, §§§P 0.001 . WTH, wildtype hypoxic; SERT+H, SERT+ hypoxic; v, vehicle treated; n, number of mice.