知柏地黄汤加减联合内分泌治疗肾阴虚型晚期前列腺癌临床研究.docVIP

知柏地黄汤加减联合内分泌治疗肾阴虚型晚期前列腺癌临床研究 　　摘要：目的 观察知柏地黄汤加减联合内分泌治疗肾阴虚型晚期前列腺癌的临床疗效及对患者潮热症状的影响。方法 将72例晚期前列腺癌患者随机分为联合组和对照组各36例，2组均采用内分泌治疗（比卡鲁胺+戈舍瑞林），联合组加服知柏地黄汤，疗程为12周，比较2组患者治疗前后血清前列腺特异抗原（PSA）、国际前列腺症状评分（I-PSS）、临床症状疗效评分、潮热发生例数及安全性指标。结果 治疗过程中，联合组和对照组各失访1例。2组治疗后PSA、I-PSS评分较治疗前均明显下降（P0.01）。联合组总有效率为94.3%（33/35），对照组为57.1%（20/35），组间比较差异有统计学意义（P0.01）。治疗后联合组潮热发生例数较治疗前减少，对照组较治疗前增多，组间比较差异有统计学意义（P0.01）。治疗过程中2组均未发生明显不良反应。结论 知柏地黄汤加减联合内分泌治疗肾阴虚型晚期前列腺癌临床疗效优于单纯内分泌治疗，且可减少潮热症状的发生。 　　关键词：知柏地黄汤；内分泌治疗；晚期前列腺癌；临床研究 　　DOI：10.3969/j.issn.1005-5304.2016.04.007 　　中图分类号：R273.72 文献标识码：A 文章编号：1005-5304（2016）04-0024-04 　　Clinical Study on Zhibai Dihuang Decoction Combined with Endocrine Therapy in Treating Kidney-yin Deficiency Type of Advanced Prostate Cancer LIU Hua， TANG Hong， GUO Zhong-cong （The First Affiliated Hospital of Hunan University of Chinese Medicine， Changsha 410007， China） 　　Abstract： Objective To observe the clinical efficacy of Zhibai Dihuang Decoction combined with endocrine therapy for kidney-yin deficiency type of advanced prostate cancer and its influence on patient symptoms of hot flashes. Methods Totally 72 cases of advanced prostate cancer patients were randomly divided into the combined group （36 cases） and the control group （36 cases）. Patients in the control group were treated with endocrine therapy， while patients in the combined group were additionally treated by Zhibai Dihuang Decoction. After 12 weeks of treatment， serum prostate specific antigen （PSA）， the international prostate symptom score （I-PSS）， the clinical symptoms score， the number of cases of hot flashes and safety index before and after treatment were observed. Results In the course of treatment， the control group and the combined group each had 1 case lost to follow up. PSA and I-PSS in the two groups significantly decreased after treatment （P0.01）. The total efficiency rate of TCM syndrome was 94.3% （33/35） in the combined group， while it was 57.1% （20/35） in the control group， with significant difference （P0.