AdvancesinStemCellTransplantationandCell.pptVIP

* OS EFS in 96 pts depending on disease state at time of HSCT. Upper line pts traqnsplanted in CR1-CR#, middle curve pts with active disease confined to the marrow but w/o circulating blasts. Lower curve shows pts with active AML in both marrow and peripheral blood. Upper curve 43 pts – plateau in EFS seemingly at 74% at 2 years. * Q6. retroviral vector issues. Adenoviral vector used for transient transfection situations Retroviral vector for stably transfected situations with low oncogenic risk (e.g. T cells) Lentivirus for stem cells (in development) Quickest to go straight here. Q2. ARIA