替罗非班对老年急性ST段抬高心肌梗死患者心肌再灌注及左心功能的影响.docVIP

替罗非班对老年急性ST段抬高心肌梗死患者心肌再灌注及左心功能的影响 【摘要】 目的 探讨替罗非班对老年急性ST段抬高心肌梗死患者的心肌再灌注与左心功能的影响。方法 112例老年急性ST段抬高心肌梗死患者按照随机数字法分为对照组和研究组， 均给予经皮冠状动脉介入治疗， 对照组术中给予常规治疗， 研究组术中给予替罗非班治疗， 观察其对心肌再灌注与左心功能的影响。结果 研究组心肌再灌注发生率明显高于对照组，两组比较差异有统计学意义（P 0.05）。研究组的左室射血分数（LVEF）明显高于对照组， 差异有统计学意义（P 0.05）。结论 老年急性ST段抬高心肌梗死患者在经皮冠状动脉介入治疗过程中应用替罗非班是可行的， 改善患者的心肌再灌注和心功能， 值得临床应用。 【关键词】 老年；急性ST段抬高心肌梗死；替罗非班；心肌再灌注；左心功能 【Abstract】 Objective To investigate the influence of tirofiban on myocardial reperfusion and left ventricular function of elderly patients with acute ST-segment elevation myocardial infarction. Methods A total of 112 elderly patients with acute ST-segment elevation myocardial infarction were randomly divided into control group and study group according to Random number method. After given percutaneous coronary intervention， patients in the control group received conventional therapy， while patients in the study group were given tirofiban treatment. The influence of tirofiban on myocardial reperfusion and left ventricular function was observed. Results The incidence of myocardial reperfusion in the study group was significantly higher than that of the control group. Difference between the two groups was statistically significant （P 0.05）. Left ventricular ejection fraction （LVEF） values of the study group was significantly higher than that of the control group， and the difference was statistically significant （P 0.05）. Conclusion Tirofiban applied in elderly patients of acute ST-segment elevation myocardial infarction patients with percutaneous coronary intervention is feasible， and it can improve myocardial reperfusion and heart function. It is worthy of clinical application. 【Key words】 Elderly patients； Acute ST-segment elevation myocardial infarction； Tirofiban； Myocardial reperfusion； Left ventricular function 老年急性ST段抬高心肌梗死是临床中常见疾病之一， 临床中常常采取保守治疗和经皮冠状动脉介入治疗， 经皮冠状动脉介入治疗能够有效的降低再梗死和提高冠状动脉再通率。但是， 在经皮冠状动脉介入治疗的过程中， 冠状动脉内存在大量的血栓， 为临床治疗带来了一定的麻烦。而替罗非班能够有效地减少血小板的聚集， 并有效的维持微循环灌注， 效果明显[1]。对老年急性ST段抬高心肌梗死患者在经皮冠状动