抗菌素多肽库纳米颗粒支架在神经再生中的应用.docVIP

抗菌素多肽库纳米颗粒支架在神经再生中的应用 伊朗塔比阿特莫达勒斯大学生物科学学院Majid Sadeghizadeh教授与Babak Bakhshinejad博士在《中国神经再生研究（英文版）》（2014，第9卷，22 期）文章中指出，噬菌体在神经细胞再生中起着重要作用。噬菌体，特别M13等线状噬菌体，因其独特的自体纳米级结构，单分散性，和巨大的遗传灵活性，是自然届存在的可高效建立功能纳米医学和纳米材料的理想病毒。噬菌体纳米材料在神经再生中主要应用包括以下2类方面：第一类是开发纳米线状噬菌体作为生物可降解和生物相容的神经组织工程支架。第二类是噬菌体肽文库在筛选神经系统不同细胞中的亲和力。生物亲和性筛选力最显著靶细胞是神经干细胞。神经干细胞的结合性肽可以用作用于治疗性基因和药物的特异性递送，从而调节神经干细胞的功能。这种调制可以被通过刺激神经发生的方法用于治疗神经变性疾病。总体而言，作者的近期的研究结果表明，噬菌体颗粒和噬菌体展示技术的巨大承诺，可用来开发先进，高效的纳米医学工具修复受损神经细胞和组织的再生。 Article: Bacteriophages and development of nanomaterials for neural regeneration by Babak Bakhshinejad, Majid Sadeghizadeh Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran Bakhshinejad B, Sadeghizadeh M. Bacteriophages and development of nanomaterials for neural regeneration. Neural Regen Res. 2014;9 22 : 1955-1958. 欲获更多资讯：Neural Regen Res Phage-based nanomaterials for regenerative medicine of the nervous system SUMMARY Bacteriophages, also abbreviated as phages, are viruses that exclusively infect bacterial cells. These viral nanoparticles represent dramatic potential for developing neural tissue engineering scaffolds. They can also be used for identification of peptides with specific binding to cells residing in different parts of the nervous system. Various benefits provided by these viral nanomaterials imply the fact that in the future they will hold a major role in formulating helpful therapeutic strategies for the field of neural regeneration. NEWS RELEASE Professor Majid Sadeghizadeh and Dr. Babak Bakhshinejad highlight in a paper in Neural Regeneration Research Vol. 9 No. 22, 2014 the critical role of bacteriophages in developing therapeutic platforms for regeneration of neural cells. Phages, particularly filamentous ones such as M13, are naturally occurring viruses that harbor several ideal characteristics for establishing efficient functional nanomedicines and nanomaterials. These characteristics include self-assembly into nanoscale structures, monodisp