CysticFibrosis-WayneStateUniversitySchoolof.ppt

Cystic Fibrosis Paolo Aquino Internal Medicine-Pediatrics January 13, 2005 Outline What is cystic fibrosis (CF)? What causes CF? What are the manifestations? How do you diagnose CF? How do you treat CF? Cystic Fibrosis Inherited monogenic disorder presenting as a multisystem disease. Typically presents in childhood 7% of CF patients diagnosed as adults Most common life limiting recessive trait among whites Cystic Fibrosis Prognosis improving 38% of CF patients are older than 18 13% of CF patients are older than 30 Median survival Males: 32 years Females: 29 years Genetics of CF Autosomal r