IntervalApproachtoAssessingAntitumorActivity.pptVIP

* * * Assessing Antitumor Activity in Preclinical Tumor Xenograft Model Department of Biostatistics St. Jude Children’s Research Hospital John(Jianrong) Wu Tumor Xenograft Model Tumor xenograft models Subcutaneous tumor model: tumor xenograft is implanted under the skin and typically located on the flank of the mouse. Orthotopic tumor model: tumor xenograft is either implanted into the equivalent organ from which the cancer originated, or where metastatsese are found in patients. D456-cisplatin tumor xenograft model Challenges A relative small number of mice (10/per group) were tes