神经延长促进损伤周围神经的再生.docVIP

神经延长：促进损伤周围神经的再生 周围神经损伤后局部微环境对损伤神经的再生起重要作用。最新研究表明，周围神经损伤后适度的张力可以促进轴突再生。美国加州大学圣地亚哥分校矫形外科与生物工程系Sameer B. Shah博士假设，近端未受损的神经可以向损伤远侧神经伸长，并且忠实地再现体内和体外创建的机械环境，这种神经延长可以跨越神经缺损，确保解剖和功能匹配到远端残端并可能加速功能恢复。作者研究团队据此研制出新型的固定器，能线性拉长近端残端向远端残端并加速与远端重新连接，促进损伤周围神经的修复与再生。此观点发表在《中国神经再生研究（英文版）》2014年8月第16期杂志上。 Article: Peripheral nerve lengthening as a regenerative strategy Kenneth M. Vaz1, Justin M. Brown2, Sameer B. Shah3 1Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA, USA; 2Department of Neurosurgery, University of California, San Diego, La Jolla, CA, USA; 3Departments of Orthopaedic Surgery and Bioengineering, University of California, San Diego, La Jolla, CA, USA Vaz KM, Brown JM, Shah SB. Peripheral nerve lengthening as a regenerative strategy. Neural Regen Res. 2014;9 16 :1498-1501. 欲获更多资讯： 文章全文请见：Neural Regen Res Peripheral nerve lengthening as a regenerative strategy Excessive mechanical loading has long been implicated in nerve injury, and thus tension is actively avoided during nerve repair. However, recent evidence suggests that moderate levels of mechanical loading may, in fact, promote neuronal growth. Sameer B. Shah and her colleagues have hypothesized that in vivo elongation of intact proximal stumps towards the injured distal stumps of severed peripheral nerves can faithfully reproduce the mechanical environment created during the above-mentioned in vivo and in vitro procedures. Such lengthening across a nerve gap may accelerate functional recovery and ensures an anatomic and functional match to the distal stump. Nerve transfers require rerouting of redundant branches or fascicles from functional nerves to functionally paralyzed recipient nerves. The transfer restores neuromuscular function in the recipient nerve, enabling individuals to execute critical tasks such as elbow extension or key pinch. However, the choice of donor nerves is often limited by anatomical proximity to the recipient, resulting in the use of an intervening graf