胎儿脐静脉移植可用于大脑中动脉损伤的修复.docVIP

Fetal umbilical vein transplantation for the repair of middle cerebral artery injury Xuhui Hou1, Yi Yuan1, Jian Yin1, Songbai Yang1, Lili Xie1, Shiji Wang2 1 Department of Vascular Surgery, China-Japan Friendship Hospital of Jilin University, Changchun 130031, Jilin Province, China2 Department of Critical Care Medicine, First Hospital of Jilin University, Changchun 130021, Jilin Province, China 窗体顶端 Abstract: It is necessary to investigate the longitudinal tensile mechanical characteristics of the middle cere-bral artery and the fetal umbilical vein prior to applying fetal umbilical vein transplantation for repair of injured middle cerebral artery. Fifteen fresh fetal umbilical vein specimens and 15 normal human fresh cadaver middle cerebral artery specimens were collected for longitudinal tensile testing at the speed of 0.5 mm/min and at normal human temperature. The results showed that under 16.0 kPa physiological stress, the strain value of fetal umbilical vein specimens was larger, while the maximal stress and elastic modulus values were less than those of middle cerebral artery specimens. Our findings indicate that fetal umbilical vein has good elastic properties and the stress-strain curve of the fetal umbilical vein is similar to that of the middle cerebral artery. Fetal umbilical vein transplan-tation can, therefore, potentially repair the injured middle cerebral artery. Key words： neural regeneration; middle cerebral artery; fetal umbilical vein; tension; stress; strain; elastic mod-ulus; biomechanics; transplantation repair; neuroregeneration; 窗体底端 Acceptance date: 2013-09-27 Cite this article: Xuhui Hou, Yi Yuan, Jian Yin, Songbai Yang, Lili Xie, Shiji Wang. Fetal umbilical vein transplantation for the repair of middle cerebral artery injury[J]. Neural Regeneration Research, 2013, 8 34 : 3249-3254.