奥沙拉嗪钠加复方黄柏液涂剂保留灌肠治疗慢性结肠炎的疗效观察.docVIP

中国肛肠病杂志2008.10（4） 奥沙拉嗪钠加复方黄柏液涂剂保留灌肠治疗 慢性结肠炎的疗效观察 浙 江 省 绍 兴 第 二 医 院 （浙江 绍兴 312000） 艾卫民 浙江省嵊州市剡湖街道中心卫生院（浙江 嵊州 312400） 黄培余 摘要 [目的]以奥沙拉嗪钠口服，复方黄柏液涂剂保留灌肠，以及奥沙拉嗪钠加复方黄柏液涂剂保留灌肠各一组。观察治疗慢性结肠炎的疗效及复发率.。[方法]采用随机，双盲对照设计进行临床试验。奥沙拉嗪钠组27例，500㎎/次,3次/d，口服；复方黄柏液涂剂组29例，每晚1次,每次100ml，保留灌肠；复合组30例，用奥沙拉嗪钠口服和复方黄柏液涂剂保留灌肠同时进行，剂量和方法同前两组，三组疗程均为30天。[结果] 奥沙拉嗪钠组27例；30天后显效13例，有效8例，无效6例， 总有效率77.8%，复发7例（25.9%）；复方黄柏液涂剂组29例；30天后显效9例，有效13例，无效 7例，总有效率77.86%，复发12例（41.3%）；复合组30例：30天后显效21例，有效8例，无效1例，总有效率96.67%，复发1例（3.33%）。经统计学处理，三组间交叉对比分别为×2 0.014、×2 3.92、×2 4.68。前两组间总有效率无统计学意义（P＞0.05）, ?奥沙拉嗪钠组和复方黄柏液涂剂组与复合组间总有效率差异显著（P＜0.05），疗效显著。 关键词；慢性结肠炎，奥沙拉嗪钠、复方黄柏液涂剂、保留灌肠 Clinical study on the effect of Retention Enema with olsalazine sodium and Fufanghuangbai liquid in the treatment of chronic colitis Ai weiming, Huang peiyu Shaoxing second Hospital ,shaoxing,zhejiang 312000 shanhu comer centeral Hospital ,shengzhou,zhejiang 312400 Adstract [Objective] there are three groups of cases with chronic colitis and treated with the olsalazine sodium,the Fufanghuangbai liquid and the olsalazine sodium combined with fufanghuangbai liquid respectively,observe the efficacy and recurrence rate in the treatment of the cases.[Methods]we designed a randomized,double blind and control study.The 27 patients in the first group took olsalazine sodium 500mg three times daily.The 29 patients in the second were given an enema with fufanghuangbai liquid 100ML once every night.The 30 patients in the combouded group,Received the two therapy methods.the same time and with the same doses and methods.The treament lasted for 30 days in the all three groups.[Results]After 30days.among the group with olsalazine sodium only ,13cases were distict ulitily,8 cases were efficiency,6 cases were ineffiency. The total effective rate was 77.8%,7 cases recurred 25.9% ,among the group with fufanghuangbai liquid only , 9 cases were distict ulitily,13 cases were efficiency,7 cases were ineffiency. The total effective rate was 77.86%.12 cases recurred 4