超微粉碎技术对三种药材粉碎效果及主要功能性成分溶出率的影响.docVIP

超微粉碎技术对三种药材粉碎效果及主要功能性成分溶出率的影响 　　摘要：对肉苁蓉、艾叶和鱼腥草3种药材分别利用普通粉碎机与超微粉碎机常温粉碎制得普通粉碎药粉与超微粉碎药粉，在扫描电子显微镜下观察药粉粉末的显微形貌特征，并利用分光光度法或高效液相色谱法对其主要功能性成分的溶出率进行测定。结果表明，3种药材的超微粉与普通粉相比粒度明显变小，且大小均匀；肉苁蓉超微粉中的毛蕊花糖苷和松果菊苷溶出率都显著高于普通粉，而其总黄酮溶出率低于普通粉，且差异极显著；艾叶超微粉中总黄酮溶出率高于普通粉，且差异显著，但挥发油含量显著低于普通粉；与鱼腥草普通粉相比，鱼腥草超微粉中总黄酮、槲皮苷与金丝桃苷的溶出率均显著提高，而鱼腥草素溶出率没有显著性差异。与普通粉相比，3种药材超微粉的粒度变小，且较为均一；但由于药材本身特性不同，主要功能性成分溶出率并没有完全增加，因此在药物生产实践中应根据不同的药材性质与现实需要选择合理的粉碎方法。 　　关键词：肉苁蓉；艾叶；鱼腥草；超微粉碎；功能性成分 　　中图分类号：R284.2 文献标识码：A 文章编号：0439-8114（2016）08-2039-06 　　DOI：10.14088/j.cnki.issn0439-8114.2016.08.030 　　Abstract： The ordinary powder and ultrafine powder of herba cistanches， wormwood leaves and herba houttuyniae was obtained by ordinary grinder and ultrafine grinding mill at room temperature， respectively. The microscopic morphology of the medicinal powder was observed by scanning electron microscopy， and the extraction rate of main functional components was determined by spectrophotometric or high performance liquid chromatography. For the three herbs， the particle size of ultrafine powder was obviously smaller and more uniform than of ordinary powder. For ultrafine powder of herba cistanche， the dissolution rate of verbascoside and echinacoside was significantly higher than ordinary powder， while the total flavonoid content was very significantly lower. For ultrafine powder of wormwood leaves， the dissolution rate of total flavonoids was significantly higher than ordinary powder， while the volatile oil content was significantly lower. For herba houttuyniae ultrafine powder， the dissolution content of total flavonoids， quercetin and hyperoside was significantly higher； while of houttuyfonate was not significantly changed. Due to the characteristics of different herbs， the dissolution rate of main functional components in ultrafine powder and ordinary powder was not the same， thus the grinding method in drug manufacturing practice should be chose depending on the target ingredients and properties of the herb. 　　Key words： he