济南大学课程设计论文课程作业.docVIP

课程设计论文 题 目 学 院 专 业 班 级 制药1001 学 生 学 号 座机电话号码039 指导教师 二〇一三年月日ABSTRACT In this paper Cefotaxime，which was prepared from 7-ACA and MAEM in triethylamine and pyridine，was subsequently reacted with 2，3-cyclopenopyridine in the presence of hexamethyldisilazane and iodine to give cefpirome dihydroiodide． It was further treated that new ion exchange resin was afforded the target compound cefpirome sulfate in 63 % overall yield based on 7-ACA ． Structure of the target compound was confirmed by1H-NMR and MS． Key words：cefpirome; antibiotics; synthesis; improvement 目 录 摘要………………