bronchialasthma课程.pptVIP

Bronchial Asthma Department of Respiratory Medicine Third Xiangya Hospital of Central South University Outline Introduction Definition Etiology Pathogenesis pathology Diagnosis Treatment Disease management recommendations Asthma: introduction Asthma is one of the most common chronic diseases worldwide Prevalence increasing in many countries, especially in children a major cause of school/work absence Asthma: introduction an increasing prevalence of asthma and incorrect treatment increase the mortality of asthma Total estimated cost of asthma was $ 6.2 billion/year in the world Asthma: introduction In a word, asthma is a global disease with increasing incidence, and it is an important cause of disability, death, and high economic cost. Increasing appreciation of asthma is a global public health problem Asthma: definition(what is asthma?) a chronic inflammatory disorder of the airways many cells and cellular elements play a role mast cells, eosinophils, T lymphocytes this inflammation causes an associated increase in airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning Asthma: definition These episodes are usually associated with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment. Asthma: definition A chronic inflammatory airway disease Airway hyperresponsiveness(AHR) Recurrent episodes of wheezing Reversible airflow obstruction Asthma: Etiology(What cause asthma?) Genetic factors a inheritable disorder Atopy Airway hyperresponsiveness Atopy Atopy, the production of abnormal amounts of IgE antibodies in response to common environmental allergens, is the strongest identifiable predisposing factor for developing asthma. Airway hyperresponsiveness AHR, the tendency of the airways to narrow too much and too easily in response to various stimuli. Asthma: Etiology Environme