细胞信号转导与肿瘤幻灯片.pptVIP

非受体型: JAK 激酶 PIP2 PLC IP3 DAG Ca++释放 PKC PI-3-K信号转导途径 The different isoforms of the Class I PI3Ks are activated by different receptors, tyrosine kinase, antigen, and integrin receptors for the Class IA family, and G protein couple receptors GPCR for the Class IB family. The PI3Ks phosphorylate the PIP2 lipid to generate the second messenger, PIP3, which is involved in the signal transduction driving several cell processes. 酪氨酸蛋白激酶系统 受体型 TPK介导的CST途径 T P K -Grb2-Sos Ras Raf MAPK 靶蛋白 磷酸化 靶基因 转 录 PI3K PKC IP3 Ca2+ DG PLC 受体TPK途径 致癌物致癌与信号转导 信号转导 理化性 致癌物 DNA 损伤 基因 突变 细胞 癌变 直接作用 肿瘤 形成 致癌物致