AlterationsofAPPprocessinginLRPcellsareisoform.pptVIP

Alterations of APP processing in LRP?/? cells are isoform independent. Claus U. Pietrzik et al. EMBO J. 2002;21:5691-5700 ?2002 by European Molecular Biology Organization Alterations of APP processing in LRP?/? cells are isoform independent. A LRP+/? and LRP?/? cells stably transfected with APP695 were analyzed for levels of APP‐αCTFs. Single clones of similar APP expression were analyzed top panel . Note the dramatic reduction in APP‐CTF expression in LRP?/? cells bottom panel . Quantitation of APP‐αCTF B and APPs C levels in LRP‐deficient CHO 13‐5‐1 and control CHO cells transfected