Clinical Research .pptVIP

Clinical Research Bridging the Gap between Basic Science and Improved Human Health FASEB Clinical Research Subcommittee What Is Clinical Research? Research conducted on humans or human tissues that makes use of patient data. Includes study of disease mechanisms, therapeutic interventions, epidemiology, and clinical trials. Aimed at understanding human disease and improving human health. Interaction between researchers and patient data is a key feature. Definitions of Clinical Research Definitions of Clinical Research Why is Clinical Research Important? Enhances our understanding of human physiology and pathophysiology. Translates basic research into medical care. Informs and drives basic research. Improves diagnostic tools and preventive care. Improves human health! What Can Clinical Research Accomplish? Research in human physiology and pathophysiology translates basic research into knowledge of disease mechanisms and medical therapeutics. Clinical trials establish safety and efficacy of new interventions. Epidemiological and behavioral research identify high risk populations with potential to benefit from prevention, early detection, or therapeutic intervention. Outcomes and health services research assess the health impact and cost-effectiveness of interventions. Physiological Research Carefully controlled studies in patients or normal subjects that are intended to understand basic physiologic mechanisms and their disruption in human disease. Translation of basic research findings (in vitro and preclinical animal investigation) to human subjects to confirm the human relevance of proposed disease mechanisms, which will inform scientifically targeted medical therapeutics. This work is usually done through General Clinical Research Centers (GCRC) and informs clinical trials. Clinical Trials Research that prospectively assigns human subjects to intervention and concurrent comparison/control groups to study the cause-and-e