Effects of Spa Therapy on Inflammation and Immune .pptVIP

Effects of Spa therapy on anti-oxidative status, inflammation, immune system Prof. Dr. M. Zeki Karagülle Spa therapy and Balneotherapy Do they have biologic effects on Immune system and Inflammation and Oxidation ? Which mechanisms and mediators are involved? Terminology Spa therapy ; a complex intervention at a spa resort, balneotherapy + others Balneotherapy ; Mineral/thermal water therapy Bathing + Drinking + Inhalation Inflammation the first response of the immune system to infection or irritation characterised by the following quintet: redness rubor , heat calor , swelling tumor , pain dolor dysfunction of the organs involved functio laesa The first four characteristics have been known since ancient times and are attributed to Celsus; functio laesa was added to the definition of inflammation by Rudolf Virchow in 1858. Immune System Spa- and Balneotherapy Studies on Anti-oxidative status Anti-oxidant status in patients with Rheumatoid Arthritis after Spa Therapy M KARAGüLLE, MZ KARAGüLLE , O KARAGüLLE, A AVCI , ? DURAK 35th Congress of ISMH, June 6-10, 2006, Istanbul The Effect of Balneotherapy on Oxidant-Antioxidant Systems in Primary OsteoarthritisHN AKSOY, N ERDO?AN, ? AKSOY, G? ERATA, AH KAYAR, MZ KARAGüLLE 35th Congress of ISMH, June 6-10, 2006, Istanbul Malondialdehyde MDA nmol/mL After 2-week spa therapy; increased in SPA group, decreased in control group No statistically significant change intergroup p 0.5 and between group p 0.2 comparisons Nonenzymatic Superoxide Radical Scavenger Activity NSSA U/mL After 2-week spa therapy; increased in both groups Statisticaly significant increase in SPA group p 0,05 Antioxidant Defense Potential AOP U/mL After 2-week spa therapy; increased in both groups ?n spa group agreater extend but , not statistically significant Discussions Increased levels of MDA although not statistically significant suggests that; Per-oxidation reactions are accelerated during or after spa therapy spa