Bladder Pharmacology Campbell-Walsh Ch 56 1948-1972.pptVIP

Bladder PharmacologyCampbell-WalshCh. 56: 1948-1972 Stephen Miller, DO Peripheral Pharmacology Muscarinic 4 different receptor subtypes based on Pharmacology (M1-M5) Human Bladder M1 M2 (Predominate) M3: Mediate cholinergic contractions Key roles in: Salivary secretion Pupillary constriction Digestive tract M3R Action Acetylcholine ? M3R ? IP3 hydrolysis (PLC) ? Intracellular Ca2+ Release = Smooth Muscle Contraction L- type Ca2+ channels have also been indicated in M3R mediated detrusor contractions M2R Coactivation could enhance response to M3: Inhibition of adenylate cyclase = suppres