血液透析与腹膜透析对终末期糖尿病肾病患者微炎症状态的影响 宋洁1.docVIP

血液透析与腹膜透析对终末期糖尿病肾病患者微炎症状态的影响 宋洁1( 李小萍2 石理华1 张建荣3 李辉1﹟ （1.武警后勤学院附属医院肾脏病科 天津 邮编：300162，2.武警医学编辑部 北京 邮编100039，3.武警总医院肾内科 北京 邮编：100039） 【摘要】 目的：比较两种不同的透析方式：血液透析（hemodialysis,HD）与非卧床持续性腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)对终末期糖尿病肾病微炎症状态的影响。 方法：选择终末期糖尿病肾病患者60例,分为HD组32例和CAPD组28例，采用酶联免疫法（ELLISA）检验透析起始、透析3个月后两组患者血清超敏C反应蛋白(hs-CRP)、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平变化。 结果：HD组与CAPD组患者透析3个月后 hs-CRP、IL-6、TNF-α水平较透析起始升高，差异有统计学意义(P0．05)；透析3个月后，HD组患者血清微炎症指标：hs-CRP、IL-6、TNF-α水平高于CAPD组，差异显著，有统计学意义(P0．05)。 结论：HD和CAPD可导致终末期糖尿病肾病患者微炎症状态进一步加重，而且HD与CAPD对微炎症的影响存在差异，HD患者微炎症反应更严重。 【关键词】血液透析；非卧床持续性腹膜透析；终末期糖尿病肾病；微炎症状态 Effect of Hemodialysis and Peritoneal on Microinflammatory State in patients with End-Stage diabetic nephropathy Song jie1,Li xiao ping2,Shi li hua1,Zhang jian rong3,LI hui 1﹟(1.The Department of Nephrology, Affiliate Hospital of Logistics College of the Chinese People’s Armed Police Forces,Tianjin300162,China; 2. Editorial Department of Medical Journal of the Chinese People’s Armed Police Forces, Beijing10039,China;3.The General Hospital of Chinese People’Armed Police Forces,Beijing10039,China) 【Abstract】 Objective: To analyze the different effects by comparing HD with CAPD on microinflammatory state in patients with End-Stage diabetic. Method: 60 patients with End-Stage diabetic nephropathy who were elected were divided into 2 groups: HD group (n=32) and CAPD group (n=28). Serum levels of hs-CRP、IL-6、TNF-αin venous blood of the patients in the two groups were detected by enzyme-linked immunosorbent assay ( ELLISA ) test before and after 3months’ dialysis. Result: Comparing with those at the beginning of dialysis，serum levels of hs-CRP、IL-6、TNF-αin patients of both groups were higher after 3 months’ dialysis,the difference was significant (P0.05) and serum levels of hs-CRP、IL -6 、TNF –αin patients of the HD group were higher than that in patients of the CAPD group ( P 0.05 ) after 3 months’ dialysis. Conclusion: Both HD and CAPD made microinflammatory state in p