母婴乙型肝炎病毒五项定量检测结果分析.docVIP

母婴乙型肝炎病毒五项定量检测结果分析 吴著球 【摘要】目的：了解母体乙型肝炎病毒五项指标定量检测状况对婴儿乙型肝炎病毒免疫力和易感性的影响。方法：收集2013年1月1日至2014年12月31日在我院住院婴儿及其母亲分娩前均进行乙型肝炎病毒五项指标定量检测的病例，并对检测结果进行统计学分析。结果：在467例产妇中HBsAg阳性17例，阳性率3.64%。467例婴儿中HBsAg全部阴性。乙型肝炎病毒表面抗体定量检测不同浓度组比较各组婴儿抗体浓度均高于母体，P值均小于0.01，差异有显著性。婴儿不同年龄乙型肝炎病毒表面抗体定量检测只有新生儿出生≤7天组母婴抗体存在明显差别，P值小于0.01。乙型肝炎病毒e抗体各组婴儿抗体浓度均低于母体，抗体增率均为负值，且在-0.10左右，各组P值均小于0.01，差异有显著性。乙型肝炎病毒核心抗体母婴配对比较表明：抗体浓度≤3 NCU/ml时，婴儿抗体浓度略高于母体，抗体增率为0.018，抗体浓度差异无统计学意义；而抗体浓度＞3 NCU/ml时，婴儿抗体浓度明显低于母体，抗体增率达-0.217，P＜0.05，差别有统计学意义。结论：①乙型肝炎病毒宫内感染的几率很低。②乙型肝炎病毒表面抗体可通过胎盘逆浓度梯度主动转运，母体抗体浓度越低，这种转运的效能越高。③非保护性乙型肝炎病毒e抗体母体胎儿间可认为是一种被动转运，而乙型肝炎病毒核心抗体在低浓度时可能存在主动转运，高浓度时则是被动转运。 【关键词】乙型肝炎病毒五项指标；定量检测；母婴 Analysis on the results of quantitative testing for hepatitis B?five blood indicators in infant mom Wu zhuqiu Fiest People’s Hospital of Nanyang,Nanyang 473010,China Objective: To quantify the influence of maternal five HBV indexes on the infants‘immunity and susceptibility to HBV. Method: The cases to quantify the five HBV indexes of the mother before delivery and infants in the first people’s hospital of NanYang from January 1, 2013 to December 31, 2014 were collected and statistically analyzed. Result: Among 467 maternal cases, 17 were HBsAg positive with 3.64% rate, whereas infants were HBsAg negative. The concentrations of infants Hepatitis B virus surface antibody were higher than the mother in all of the groups with different concentration, P was less than 0.01 which means the difference is significant. When cases were grouped based on infant’s age, only the infants with less than 7 days showed a significant difference in the Anti-HBs concentration among the mothers and infants at P 0.01. The concentrations of Antibody to Hepatitis B virus e antigen were lower than the mother in all of the groups with the significant difference at P 0.01 and the uprate of Anti-HBe was negative. The pairwise comparison of Antibody to Hepatitis B virus core antigen concentration of mother and infants showed that when the antibody concentration was l